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. 2018 Jul 13;9(54):30450–30464. doi: 10.18632/oncotarget.25765

Figure 7. Chk1 inhibitor PF477736 reduces melanoma tumor growth.

Figure 7

Tumor xenografts of A375-PLX-R melanoma spheroid cells were injected in each front flank of female nude mice. Drug treatments were initiated at the time of tumor cell injection. The mice were injected with 15 mg/Kg body weight of Chk1i (PF477736) or DMSO for three days per week and/or 20 mg/Kg body weight of PLX4032 by oral gavage. Tumor volume were measured every week. (A) The mice receiving PF477736 alone and PF477736+PLX4032, but not PLX4032 alone, have substantially smaller tumor than the controls after week 5 and week 6 with co-treatment showing more significance. The error bars reported are the standard deviations of the averages from six tumors and the P-value was calculated by Student's t-test. One star indicates P < 0.1 and two stars indicate P < 0.05. (B) Two representative tumors from each treatment group are shown.