Table 1.

Human P450: Coupling efficiency (Product/NADPH ratio)

P450	Substrate	% coupling efficiency	Reference
1A1	Phenacetin	2.5	[58]
1A2	Methanol	7.5	[58, 59]
	7-Ethoxycoumarin	1.2
	Phenacetin	5.1
2A6	Coumarin	25	[60]
2B6	17-α-ethynylestradiol	48	[61]
	Efavirenz	42
2C9	(S)-flurbiprofen	21	[62]
	(S)-Warfarin	4
2D6	Bufuralol	39	[63, 64]
	3-Methoxyphenylethylamine	43
	4-Methoxyphenylethylamine	42
2E1	N-Nitrosodimethylamine	5.6 and 59 (± b5)	[65]
2J2	Ebastine	2–17	[66]
3A4	Testosterone	10–16	[67]
4A11	Lauric acid	31	[68]
17A1	Progesterone	22, 41	[69, 70]
	17α-Hydroxyprogesterone	1.3, 10
	Pregnenolone	97, 61
	17α-Hydroxypregnenolone	4, 44
19A1	Androstenedione	5	[71]
	19-Hydroxy androstenedione	34
	19-Aldehyde androstenedione	33