Table 1.

Sensitivity of measures obtained at the time of hypoglycemia to diagnose congenital hyperinsulinism

	Definition	Sensitivity, %	Specificity, %
Detectable insulin	any detectable value	82.2%	100%
Elevated C-peptide	≥0.5 ng/mL	88.5%	100%
Suppressed IGFBP1	≤ 110 ng/mL	85%	96.5%
Suppressed β-hydroxybutyrate	<1.8 mM	100%	100%
Suppressed free fatty acids	<1.7 mM	86.9%	100%
Positive glycemic response to 1 mg glucagon injection	Increased in plasma glucose ≥30 mg/dL	88.9%	100%

Reproduced with permission from (5).