Unicellular organisms have two distinct nutrient pathways (PII and chemoreceptors), while fungi evolved three distinct nutrient-sensing pathways (SPS, Snf3/Rgt2, and MEP2). are denoted, followed by the sensing pathways that are conserved from yeast to man. Blue bars indicate the presence of the nutrient-sensing pathways used by different organisms. (Abbreviations: AMPK, 5′ adenosine monophosphate-activated protein kinase; GCN2, general control nonderepressible 2; MEP, 2-C-methyl-D-erythritol 4-phosphate; SPS, Ssy1-Ptr3-Ssy5; TOR, target of rapamycin)
Reproduced with permission from Chantranupong L, Wolfson RL, Sabatini DM. Nutrient-sensing mechanisms across evolution. Cell. 2015; 161:67-83.