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. 2018 Mar 9;34(16):2817–2825. doi: 10.1093/bioinformatics/bty133

Table 1.

Preliminary support by pre-clinical or clinical studies showing the therapeutic potential of the proposed candidates

Disease Proposed candidate Pre-clinical/clinical evidence ClinicalTrials.gov ID
IPF Sunitinib (Grimminger et al., 2010; Knoerzer et al., 2013; Richeldi et al., 2011)
Dabrafenib (Madala et al., 2012; Olsen et al., 2014; Yoshida et al., 2002)
Nilotinib (Abdollahi et al., 2005; Allen and Spiteri, 2001; Antoniades et al., 1990; Cao et al., 2000; Chaudhary et al., 2007; Grimminger et al., 2015; Homma et al., 1995; Rhee et al., 2011)
NSCLC Sunitinib (Novello et al., 2011; Socinski et al., 2006) NCT00372775, NCT00092001, NCT00864721, NCT00693992
Sirolimus (Boffa et al., 2004; Ekman et al., 2012; Gridelli et al., 2008; Sarkaria et al., 2007) NCT00923273
Everolimus (Gridelli et al., 2008; Price et al., 2010; Soria et al., 2009) NCT01061788
Ponatinib (Chao et al., 2012; Chase et al., 2013; Gainor and Shaw, 2013; Gautschi et al., 2017; Ren et al., 2013; Thomas et al., 2015) NCT01813734
Prostate cancer Podophyllotoxin (Benzina et al., 2015; Chen et al., 2013; Choi et al., 2015; Gordaliza et al., 2000; Hu et al., 2016; Kim et al., 2013; Ma et al., 2016)
Acetylsalicylic acid (Bilani et al., 2017; Choe et al., 2012; Habel et al., 2002; Jacobs et al., 2005; Ma and Brusselaers, 2017; Nelson and Harris, 2000; Rothwell et al., 2011; Skriver et al., 2016) NCT02757365, NCT03103152, NCT02804815
Papaverine (Goto et al., 1999; Huang et al., 2017; Savai et al., 2010)
Mefloquine (Geng et al., 2010; Sharma et al., 2012; Yan et al., 2013b)
Vorinostat (Bradley et al., 2009; Carter et al., 2016; Detchokul and Frauman, 2011; Kaushik et al., 2015) NCT00330161, NCT00589472
Sirolimus (Amato et al., 2008; Chamie et al., 2008; Imrali et al., 2016; Rai et al., 2010) NCT00311623, NCT02565901
Breast cancer Captopril (Jones et al., 2004; Kast and Halatsch, 2012; Krusche et al., 2013; Namazi et al., 2014; Rundle-Thiele et al., 2016; Rooprai et al., 2001) NCT00086723
Glibenclimiade (Abdul and Hoosein, 2002; Núñez et al., 2013; Payen et al., 2001; Qian et al., 2008; Rong et al., 2013; Yasukagawa et al., 2012)
Fluorometholone (Karmakar et al., 2013; Keith, 2008; Lin and Wang, 2016)
Etoposide (Atienza et al., 1995; Yuan et al., 2012, 2015) NCT01492556, NCT00026949, NCT01589159
Colchicine (Sun et al., 2016)
Tretinoin (Budd et al., 1998; Garattini et al., 2012; Lu et al., 2005; Paroni et al., 2012; Sutton et al., 1997)

Note: These candidates are currently FDA-approved but for other indications.