Figure 6.

Prevalence of tampering with an abuse-deterrent formulation and comparator products by dissolving in the mouth among oral abusers. *Crush-resistant tablet (CRT) products significantly greater than comparator products at P = 0.0003. ^†CRT products significantly greater than comparator products at P = 0.0006. ^‡CRT products significantly greater than comparator products at P < 0.0001. Note: The denominator for each drug category is individuals who report any oral abuse of at least one of the products included in the category (see Table 1). The numerator is individuals who abused at least one of the products in the category by dissolving in the mouth (e.g., by sucking on tablet). CI = confidence interval; CRT = crush-resistant tablet; ER = extended-release; IR = immediate-release; SE = single entity.