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. 2017 Jul 8;19(8):1613–1627. doi: 10.1093/pm/pnx151

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© 2017 American Academy of Pain Medicine.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Prevalence of tampering with an abuse-deterrent formulation and comparator products by dissolving in liquid and drinking among oral abusers. *Crush-resistant tablet (CRT) products significantly less than comparator products at P = 0.0066. ^†CRT products significantly less than comparator products at P = 0.0047. Note: The denominator for each drug category is individuals who report any oral abuse of at least one of the products included in the category (see Table 1). The numerator is individuals who abused at least one of the products in the category by dissolving in a liquid and drinking. CI = confidence interval; CRT = crush-resistant tablet; ER = extended-release; IR = immediate-release; SE = single entity.