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. Author manuscript; available in PMC: 2019 May 15.
Published in final edited form as: Cancer Res. 2018 Mar 14;78(10):2760–2769. doi: 10.1158/0008-5472.CAN-17-2538

Fig 1. MPO mediated the relationship between rs2333227 C>T polymorphism and colorectal cancer patients’ survival.

Fig 1

(A) Schematic of the study. (B) MPO rs2333227 genotypes and CRC survival in a dominant genetic model in all patients. (C) Protein expression of MPO obtained by IHC assay in human CRC and adjacent tissues TMA. (D) The distribution of MPO protein expression of human CRC and adjacent tissues TMA in patients carrying three rs2333227 genotypes. P values were calculated with the Wilcoxon test. (E) MPO rs2333227 genotypes and protein expression of MPO in human CRC and adjacent tissues TMA. ***P < 0.001, NS means no significance. (F) MPO rs2333227 genotypes and CRC survival in a dominant genetic model in those who was used to analysis MPO expression (Log-rank P <0.001). (G) The relationship between MPO protein expression and CRC patients’ survival (Log-rank P <0.001). KM analysis was calculated with 1005 CRC patients (H) Schematic of mediation model for rs2333227 C>T polymorphism, MPO protein level, and CRC patients’ survival.