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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Cancer Lett. 2018 Jul 6;433:259–272. doi: 10.1016/j.canlet.2018.07.004

Fig. 6. Docking of SIS3 in the drug-binding pocket of ABCB1 and ABCG2.

Fig. 6.

Binding modes of SIS3 with (A) homology modeled ABCB1 and (B) ABCG2 protein structure (PDB:5NJG) were predicted by Acclerys Discovery Studio 4.0 software as described in Materials and methods. SIS3 is shown as a molecular model with the atoms colored as carbon- gray, hydrogen-light gray, nitrogen-blue and oxygen-red. The same color scheme is used for interacting amino acid residues. Dotted lines indicate proposed interactions.