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. Author manuscript; available in PMC: 2018 Aug 9.
Published in final edited form as: Scand Stat Theory Appl. 2013 May 7;41(1):104–140. doi: 10.1111/sjos.12013

Table 5:

Specifics of the TMLE group sequential testing procedure

Ψ0 Ψ1 Imax
1.264 1.664 57.927
Step k 1 2 3 4
Rejection boundary 2.734 2.305 2.005 1.715
α-spending 0.3125% 0.9375% 1.5625% 2.1875%
Step k 1 2 3 4
Futility boundary −0.976 0.132 0.961 1.715
β-spending 0.625% 1.875% 3.125% 4.375%