Fig. 1.

Immobility induced by the 5-day paradigm of forced swimming (FS). A, Immobility as assessed by the immobility time during the 5 consecutive days and on day 33 in WT and 3xTg (Tg) mice. The immobility time (in seconds) over the 10-min swimming time was longer on day 5 than on day 1 in both groups. On day 33, it became shorter than on day 5 in the Tg group, but not in the WT group, indicating that there was recovery of the immobility time in the Tg group during the last 4 weeks. ††, P < 0.001; *, P < 0.05.