Figure 2.

Overview of curation of toxicity values and probabilistic dose–response workflow. Blue boxes relate to the identification, curation, and extraction of chemical reference doses (RfDs); orange boxes relate to the automated workflow for replacing RfDs with probabilistic dose-response estimates. Note: The number of probabilistic dose-response estimates (1,522) exceeds the number of endpoints-specific RfDs (1,464) because some RfDs did not specific whether a continuous or dichotomous endpoint was used, so both possibilities were evaluated in the probabilistic approach (see Figure 3B). CI, Confidence Interval; POD, Point of Departure; UF, Uncertainty factor; ${{\text{HD}}_{\mathrm{M}}}^{\mathrm{I}}$, Human dose associated with an effect of magnitude M and population incidence I.