Skip to main content
. 2017 Mar 18;2:63–71. doi: 10.1016/j.ibror.2017.03.002

Table 1.

The basic properties of CaV2.2 with mutations in the IQ motif.

Co-expression V1/2 (mV) Slope (mV) I30/Ca2+ (pA/pF) R250/Ca2+ (%) R250/Ba2+ (%)
CaV2.2 Mock 18.7 ± 2.7
n = 20		 6.2 ± 0.8
n = 20		 −71.1 ± 8.4
n = 37		 17.4 ± 2.3
n = 31		 79.0 ± 2.5
n = 13
CaM 13.5 ± 2.7
n = 8		 4.6 ± 1.0
n = 8		 −29.9 ± 11.7*
n = 10		 23.8 ± 5.1
n = 11		 60.7 ± 5.2*
n = 10
CaM12 24.7 ± 2.4
n = 4		 7.1 ± 0.6
n = 4		 −170.3 ± 25.7**
n = 6		 45.1 ± 4.2*
n = 11		 68.7 ± 4.3*
n = 8
CaM34 25.5 ± 3.2
n = 5		 7.7 ± 1.3
n = 5		 −78.0 ± 16.5
n = 8		 45.0 ± 4.3*
n = 13		 82.5 ± 3.8
n = 6
CaM1234 21.9 ± 2.9
n = 16		 5.9 ± 0.8
n = 16		 −51.8 ± 11.3*
n = 11		 41.0 ± 4.1*
n = 17		 82.1 ± 4.8
n = 5
CaV2.2IF/AF Mock 31.6 ± 1.9
n = 7		 8.8 ± 1.2
n = 7		 −38.5 ± 9.4
n = 17		 21.5 ± 4.0
n = 17		 68.5 ± 3.9
n = 4
CaM 26.2 ± 3.4
n = 5		 8.6 ± 1.9
n = 5		 −52.8 ± 15.0
n = 9		 24.9 ± 3.5
n = 8		 64.7 ± 6.0
n = 11
CaM12 15.4 ± 5.7
n = 5		 6.8 ± 1.6
n = 5		 −109.5 ± 40.9
n = 7		 45.2 ± 2.8
n = 8		 61.5 ± 5.5
n = 5
CaM34 37.7 ± 2.5
n = 5		 14.2 ± 3.2
n = 5		 −23.7 ± 7.9
n = 12		 25.0 ± 4.1
n = 12		 67.6 ± 5.5
n = 6
CaM1234 30.7 ± 2.8
n = 5		 9.1 ± 0.6
n = 5		 −33.3 ± 9.3
n = 16		 33.5 ± 7.6
n = 7		 69.5 ± 8.6
n = 5
CaV2.2IF/AA Mock 41.4 ± 2.0
n = 6		 13.2 ± 1.1
n = 6		 −13.4 ± 3.3
n = 9		 19.5 ± 2.6
n = 6		 57.7 ± 4.8
n = 6
CaM 30.0 ± 4.9
n = 6		 7.9 ± 2.1
n = 6		 −60.5 ± 19.9
n = 9		 25.2 ± 5.7
n = 7		 63.4 ± 6.8
n = 4
CaM12 10.6 ± 13.1
n = 3		 6.4 ± 2.1
n = 3		 −118.8 ± 41.3
n = 4		 37.8 ± 5.6
n = 6		 82.6 ± 4.3
n = 4
CaM34 7.6 ± 10.1
n = 3		 0.8 ± 0.5
n = 3		 −63.1 ± 20.3
n = 7		 22.5 ± 2.6
n = 5		 63.4 ± 6.8
n = 3
CaM1234 25.0 ± 6.4
n = 4		 8.1 ± 2.5
n = 4		 −20.0 ± 4.4
n = 9		 16.0 ± 8.1
n = 8		 42.7 ± 3.1
n = 3

Data are presented as the mean ± SEM and were analyzed by one-way ANOVA with Fisher’s post hoc test. *: p < 0.05 and **: p < 0.01 when compared to the Mock group.