Table S1. Pharmacotherapy points according GINA steps. 2 times for week 1 point .
| GINA step | First Choice | Second Choice | Score |
|---|---|---|---|
| Step 1 | No need continuous control therapy | 0 point | |
| low dose ICS <2 times for week.- SABA >2 times for week | 1 point | ||
| Step 2 | Low dose ICS | LTRA. Low dose theophyline | 2 points |
| Step 3 | Low dose ICS/LABA | Medium dose of ICS dose | 3 points |
| High dose of ICS dose. - Low dose ICS/LABA +LTRA (or +theophylline) | 4 points | ||
| Step 4 | Medium dose of ICS | 4 points | |
| Step 5 | Tiotropium*. - Omalizumab - Mepoluzumab | 6 points | |
| Add low dose OCS | 7 points |
LTRA: Leukotriene receptor antagonists. SABA: Short-acting beta2-agonist; ICS: inhaled corticosteroids; OCS: Oral corticosteroids; LABA: long-acting beta2-agonist; med: medium dose; OCS: oral corticosteroids
Low, medium, and high dose of the different ICS was defined according to GINA guideline. Tiotropium was only for children over 12 years.