Fig 3. Systolic BP before and after treatment with ARBs for 3 days.

Systolic BP was measured before (day 0) and after (day 3) feeding mice chow containing losartan (n = 15, green), irbesartan (n = 15, blue) or telmisartan (n = 15, violet) at 2 g drug/kg chow, or normal chow (n = 8, orange) available ad libidum. Compared to mice fed normal chow, mice fed losartan, irbesartan or telmisartan chow had significantly lower BP (p < 10⁻⁴). Box plots show the median (thick line), first and third quatriles (lower and upper box sides), with vertical lines representing 5^th and 95^th percentiles. Data outside the 5^th to 95^th percentiles are shown as individual data points (black symbols).