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. 2018 Aug 9;13(8):e0201719. doi: 10.1371/journal.pone.0201719

Fig 4. Change in IOP after treatment with ARBs for 3 and 7 days.

Fig 4

Significant reductions of IOP were found for mice treated with irbesartan (p = 0.016 and 0.013) and telmisartan (p = 0.012 and 0.008) at day 3 and 7, respectively, compared to mice fed normal chow, but not for losartan treated mice. IOP decreased significantly faster for mice treated with irbesartan (p = 0.030) and telmisartan (p = 0.019), compared to mice fed normal chow, while losartan had no significant effect. Symbols and error bars represent mean and 95% confidence intervals; orange: normal chow, green: losartan, blue: irbesartan, purple: telmisartan. Data are from 14–17 mice/treatment for days 0 and 3 and 10 mice/treatment for day 7. Median IOP values for day 0 were 17.2, 16.9, 17.0 and 16.7 for normal, losartan, irbesartan and telmisartan-treated mice, respectively.