Table 1. Physiologic parameters given as mean ± SD.
| OAI | LAV | Ctr | ||
|---|---|---|---|---|
| PaO2/FiO2 [mmHg] |
Baseline | 504±150 | 448±41 | 462±34 |
| 0h | 102±36*# | 162±49* | 595±36 | |
| 3h | 184±78* | 200±60* | 445±20 | |
| 6h | 241±145* | 231±42* | 426±48 | |
| etCO2 [mmHg] |
Baseline | 39±3 | 40±2 | 40±1 |
| 0h | 43±3* | 40±2 | 37±4 | |
| 3h | 42±4 | 39±3 | 39±3 | |
| 6h | 43±4 | 39±4 | 38±3 | |
| Vt [ml/kg] |
Baseline | 7.0±0.5 | 7.2±0.5 | 7.2±0.3 |
| 0h | 6.8±0.4 | 7.3±0.5 | 7.4±0.4 | |
| 3h | 7.1±0.4 | 7.3±0.3 | 7.2±0.4 | |
| 6h | 7.2±0.5 | 7.2±0.4 | 7.1±0.3 | |
| Ppeak [cm H2O] |
Baseline | 16±3 | 16±1 | 16±3 |
| 0h | 28±5* | 28±4* | 15±2 | |
| 3h | 30±5* | 27±4* | 15±2 | |
| 6h | 29±5* | 27±4* | 16±2 | |
| Pmean [cm H2O] |
Baseline | 8±1 | 9±2 | 8±1 |
| 0h | 12±2 | 14±6* | 8±1 | |
| 3h | 16±2* | 14±5* | 8±1 | |
| 6h | 16±2* | 13±4* | 8±1 | |
| PEEP [cm H2O] |
Baseline | 5±0 | 5±1 | 5±0 |
| 0h | 6±2 | 6±1 | 5±0 | |
| 3h | 10±2*# | 7±2* | 5±0 | |
| 6h | 11±2*# | 7±1 | 5±0 | |
| MAP [mmHg] |
Baseline | 80±15 | 76±14 | 78±7 |
| 0h | 75±4 | 78±7 | 79±7 | |
| 3h | 73±5 | 76±9 | 72±5 | |
| 6h | 69±4 | 78±11 | 73±9 | |
| MPAP [mmHg] |
Baseline | 15±3 | 17±3 | 17±4 |
| 0h | 36±2*# | 27±5* | 15±3 | |
| 3h | 28±5* | 27±10* | 15±3 | |
| 6h | 26±5* | 22±3 | 17±4 | |
| CO [l/min] |
Baseline | 3.3±0.7 | 3.7±0.7 | 3.5±0.5 |
| 0h | 3.3±0.6# | 4.4±0.7 | 3.6±0.9 | |
| 3h | 3.2±0.5# | 4.6±1.0 | 3.6±0.7 | |
| 6h | 3.4±0.4# | 4.2±0.6 | 3.5±0.7 | |
| EVLWI [ml/kg] |
Baseline | 10±1 | 10±1 | 11±2 |
| 0h | 22±7*# | 15±1 | 12±2 | |
| 3h | 22±10*# | 14±2 | 13±2 | |
| 6h | 22±7*# | 14±4 | 12±1 |
* p < 0.05 vs Ctr
# p < 0.05 vs. LAV
(Abbreviations: etCO2 = endtidal carbon dioxide; Vt = tidal volume; Ppeak = airway peak pressure; Pmean = airway mean pressure; PEEP = positive endexpiratory pressure; MAP = mean arterial pressure; MPAP = mean pulmonary arterial pressure; CO = cardiac output; EVLWI = extravascular lung water index)