Recently described epigenetic changes in oral carcinoma induced by Alcohol and/or Tobacco. The representative progression model of oral carcinoma shows some of the epigenetic alterations described in different stages of oral carcinoma progression. Genes that have altered methylation patterns throughout the gene are in orange, genes described to be subject to promoter hypermethylation are in black, microRNAs (miRNAs) in yellow and long non-coding RNAs (lncRNAs) in red, modified histones are in purple (me, methylation; ac, acetylation). OPML, Oral pre-malignant lesions. The lower blue panel represents the loss of global (genome wide) methylation (hypomethylation) throughout the progression. These alterations/changes have been described influenced by the consumption of ethanol (represented by the wine glass cartoon) and/or tobacco (represented by the cigarette cartoon). This figure is original and was created by the authors Y. Ghantous, Juliana L Schussel and Mariana Brait.