Table 4.
Aldosterone synthase SNPs and plasma glucose levels
| Glucose trait | Lys173/Arg
|
Intron 1 SNP
|
||||||
|---|---|---|---|---|---|---|---|---|
| Lys/Lys | Lys/Arg | Arg/Arg | P value | C/C | C/T | T/T | P value | |
| Fasting | ||||||||
| Raw | 94.1 (17.7) | 92.6 (14.2) | 102 (27.4) | 94 (17.2) | 94.7 (19.4) | 90.6 (12.4) | ||
| Residual | −1.01 (37.5) | −1.8 (30.6) | 15.98 (32.9) | 0.000017 | 0.21 (35.1) | −1.37 (34.4) | 8.09 (39.8) | 0.2 |
| OGTT60 | ||||||||
| Raw | 177.3 (47.6) | 173.3 (47.3) | 188.8 (59.1) | 177.7 (49.3) | 174.9 (47.6) | 171.3 (43) | ||
| Residual | 0.006 (0.26) | −0.02 (0.26) | 0.067 (0.29) | 0.017 | 0.003 (0.26) | 0.004 (0.26) | −0.05 (0.24) | 0.4 |
| OGTT120 | ||||||||
| Raw | 143.3 (49.8) | 140 (48.2) | 158.1 (65) | 143.9 (52.1) | 139.9 (48.7) | 146.5 (43.9) | ||
| Residual | 0.01 (0.32) | −0.03 (0.31) | 0.1 (0.35) | 0.0019 | 0.005 (0.32) | −0.005 (0.31) | 0.01 (0.32) | 0.9 |
Mean and SD for each genotype are given. Residuals were obtained after regressing glucose values on body mass index (BMI), age, gender, ethnicity, and geographical origin. For the sake of clarity, mean values in the untransformed scale (Raw, in mg/dl) are also given. The P values were obtained from variance-component analysis, allowing for familial correlations in glucose levels, using the program solar.