Table 5.
Aldosterone synthase genotypes and fasting glucose levels by ethnicity, geographical origin, medication status, and within siblingships
| Strata | Genotype
|
||
|---|---|---|---|
| Lys/Lys (N) | Lys/Arg (N) | Arg/Arg (N) | |
| Ethnicity | |||
| Chinese | 91.8 ± 16 (553) | 90.7 ± 12.1 (401) | 100.8 ± 30.6 (74) |
| Japanese | 101.7 ± 20.9 (162) | 97.7 ± 17.9 (145) | 104.8 ± 20.9 (33) |
| Site* | |||
| SF Bay | 95.2 ± 15.0 (89) | 92.1 ± 9.6 (42) | 102.7 ± 23 (10) |
| Hawaii | 101.3 ± 23 (170) | 97.6 ± 17.6 (158) | 104.3 ± 17.9 (34) |
| TSGH | 94.8 ± 16.6 (135) | 90.8 ± 10.0 (76) | 104 ± 11.4 (15) |
| NTU | 91.5 ± 14.0 (97) | 92.9 ± 14.1 (72) | 106.6 ± 58.2 (17) |
| VGH | 88.7 ± 13.7 (224) | 89.2 ± 12.2 (198) | 95.9 ± 14.6 (31) |
| Medication† | |||
| UL | 88.8 ± 11.0 (182) | 87.9 ± 9.4 (140) | 92.7 ± 12.2 (28) |
| UH | 92.3 ± 14.0 (74) | 93.2 ± 13.1 (50) | 127.0 ± 70.5 (11)‡ |
| MH | 96.4 ± 19.8 (459) | 94.3 ± 15.5 (356) | 101.8 ± 15.7 (68) |
| Sibships | |||
| Families with Arg/Arg subjects | 95.9 ± 9.6 (22) | 93.7 ± 10.7 (69) | 102.6 ± 31.5 (65) |
| Families without Arg/Arg subjects | 93.9 ± 17.8 (693) | 92.4 ± 14.7 (477) | |
Mean ± SD for fasting glucose level (mg/dl) are given.
*
Geographical origin of subjects. SF Bay, San Francisco Bay area; TSGH, Tri-Services General Hospital, Taipei, Taiwan; NTU, National Taiwan University, Taipei, Taiwan; VGH, Veterans General Hospital, Taipei/Taichung, Taiwan.
†
UL, unmedicated low-normotensive; UH, unmedicated hypertensive; MH, hypertensive subjects taking antihypertensive medication.
‡
The median for this group is 107.0 mg/dl.