Table 3.

Multivariable model of mortality

	In-hospital mortality (N = 514)
Characteristic	Adjusted Odds ratio (95% CI)	P-value
Average daily RBC transfusion volume (10 mL/kg)	1.09 (1.02, 1.16)	0.009
Bleeding requiring a transfusion on any study day	1.23 (0.79, 1.92)	0.366
Primary ECMO indication		0.042
Respiratory	Reference
Cardiac	1.48 (0.87, 2.49)
ECPR	2.40 (1.21, 4.76)
Mean daily partial pressure of oxygen in arterial blood (10 mmHg)	1.04 (1.02, 1.07)	0.002
Hepatic organ failure on at least one study day	2.46 (1.60, 3.78)	<.001
Renal organ failure on at least one study day	2.49 (1.61, 3.85)	<.001
Immunocompromised	2.83 (1.29, 6.20)	0.010
Chronic neurologic condition	0.20 (0.04, 0.97)	0.046
Meconium aspiration syndrome	0.15 (0.04, 0.55)	0.004
Congenital diaphragmatic hernia	2.82 (1.42, 5.60)	0.003

RBC = red blood cell. ECMO = extracorporeal membrane oxygenation. ECPR = extracorporeal cardiopulmonary resuscitation. Additional variables which were considered for inclusion in the multivariable model include: weight, pre-ECMO PRISM III score, baseline immunocompromised state, ICU location of ECMO care, mode of ECMO, hospital LOS prior to ECMO, ICU LOS prior to ECMO, massive transfusion on any study day, mean daily central venous oxygen saturation (SvO₂), mean daily partial pressure of oxygen in arterial blood, duration of ECMO, mean daily ECMO flow rate, hepatic organ failure on at least one study day, renal organ failure on at least one study day, thrombotic event, and diagnoses of: cardiac arrest, acquired cardiovascular disease, congenital cardiovascular disease, pertussis or sepsis, neurologic condition, meconium aspiration syndrome, congenital diaphragmatic hernia, persistent pulmonary hypertension of the newborn, and congenital anomaly or chromosomal defect.