Figure 3.

Dose–response for the antinociceptive effect of supraspinal gabapentin (GP) in paclitaxel (Taxol)-treated mice. Gabapentin was administered i.c.v. at 30 (n = 14), 50 (n = 8), or 100 μg (n = 9) to paclitaxel-treated mice. Both the 50 and 100 μg doses reversed mechanical allodynia of the hind paw; the low dose (30 μg) did not. Saline i.c.v. had no effect on mechanical thresholds (n = 8, 1-way ANOVA, the Tukey multiple comparisons test; df = 4; F = 12.61). Data are mean ± SEM. ANOVA, analysis of variance; i.c.v., intracerebroventricular. ** P < 0.01.