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. 2018 Jul 17;3(4):e659. doi: 10.1097/PR9.0000000000000659

Figure 6.

Figure 6.

Supraspinal gabapentin (GP) requires noradrenergic descending controls to relieve pain. Conditioned place preference scores in seconds of mice for the i.c.v. saline-paired (open bars) and 100-μg i.c.v. GP-paired (filled bars) chambers: mice received i.t. saline (black bars, n = 8) or i.t. yohimbine (5.0 μg, red bars, n = 6). Mice that received i.t. saline show a preference for the GP-paired side (*P < 0.05; the Student t test compared with the saline-paired side). Yohimbine blocked the pain-relieving effect of supraspinal GP. Data are mean ± SEM. CPP, conditioned place preference; i.c.v., intracerebroventricular; i.t., intrathecal; n.s., not significant.