Table 3.
Baseline predictors of switching from efavirenz-containing ART, among 3,710 persons new efavirenz users in CNICS.
| Baseline Characteristics | Bivariable | Multivariable1 | ||
|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | |
| Prior mono or dual ARV use | ||||
| No | 1.00 | -- | -- | |
| Yes | 1.07 (0.73, 1.61) | 0.73 | -- | -- |
| Year initiated ART | ||||
| 1999–2006 | 1.00 | 1.00 | ||
| 2007–2011 | 1.64 (1.36, 1.98) | <0.01 | 1.70 (1.40, 2.05) | <0.01 |
| 2012–2015 | 3.24 (2.59, 4.05) | <0.01 | 3.68 (2.93, 4.62) | <0.01 |
| Age, per year | 0.99 (0.99, 1.00) | 0.14 | -- | -- |
| Gender | ||||
| Male | 1.00 | -- | -- | |
| Female | 1.16 (0.94, 1.44) | 0.16 | -- | -- |
| Race/ethnicity | ||||
| White, non-Hispanic or Other | 1.00 | 1.00 | ||
| Black, non-Hispanic | 1.15 (0.98, 1.36) | 0.09 | 1.08 (0.90, 1.29) | 0.40 |
| Hispanic | 0.97 (0.78, 1.22) | 0.82 | 1.00 (0.79, 1.26) | 0.99 |
| HIV risk group | ||||
| MSM or Other | 1.00 | -- | -- | |
| IDU | 1.03 (0.80, 1.31) | 0.83 | -- | -- |
| Heterosexual | 1.03 (0.87, 1.23) | 0.71 | -- | -- |
| Antidepressant use | ||||
| No on antidepressants | 1.00 | -- | -- | |
| On antidepressants | 1.09 (0.88, 1.34) | 0.45 | -- | -- |
| Previous mental health diagnosis | ||||
| No | 1.00 | 1.00 | ||
| Yes | 1.33 (1.12, 1.59) | <0.01 | 1.33 (1.11, 1.59) | <0.01 |
| Previous medical diagnosis | ||||
| No | 1.00 | -- | -- | |
| Yes | 1.08 (0.86, 1.34) | 0.51 | -- | -- |
| CD4 count, cells/mm3 | ||||
| ≤ 350 | 1.00 | -- | -- | |
| >350 | 1.07 (0.91, 1.27) | 0.41 | -- | -- |
1
Model adjusted for all variables in the table and site.