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Hepatic peroxisome proliferation (mean ± SD) of male or female C57Bl/6 mice given 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate via gavage for 28 days. Acyl-CoA oxidase activity was measured in archived livers that had been collected from animals 1 day after exposure ended. *A statistically significant increase in acyl-CoA oxidase activity relative to the 0 mg/kg group of the matching sex (P < .05).
