TABLE 1.

Splenic lymphocyte subpopulations in adult C57BL/6 male and female mice orally exposed to 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate for 28 days

Test compound (mg/kg)	Relative spleen wta	B cells (cells × 107)	CD4+(cells × 107)	CD8+(cells × 107)	CD4+/CD8+(cells × 106)	CD4−/CD8−(cells × 106)
Males
0	3.81 ± 0.40	2.76 ± 1.07	2.36 ± 0.89	1.41 ± 0.51	0.60 ± 0.23	2.67 ± 1.39
1	3.59 ± 0.61	3.69 ± 0.78	3.27 ± 0.80	2.03 ± 0.37	0.73 ± 0.16	4.96 ± 1.25
10	3.78 ± 0.47	2.94 ± 1.00	2.55 ± 0.85	1.53 ± 0.48	0.59 ± 0.13	3.46 ± 0.96
100	4.07 ± 0.99	3.88 ± 1.22	3.62 ± 1.08	2.15 ± 0.61*	1.02 ± 0.27*	5.32 ± 2.27*
Females
0	5.34 ± 0.39	3.25 ± 1.11	2.54 ± 0.83	1.55 ± 0.45	0.57 ± 0.17	6.60 ± 2.34
1	5.15 ± 0.56	4.26 ± 0.77	3.39 ± 0.78	1.96 ± 0.19	0.85 ± 0.25	7.62 ± 2.09
10	5.01 ± 0.77	3.72 ± 0.70	2.67 ± 0.33	1.70 ± 0.40	0.74 ± 0.36	7.00 ± 4.06
100	4.65 ± 0.56*	3.33 ± 1.11	2.84 ± 0.97	1.62 ± 0.47	0.77 ± 0.44	5.93 ± 2.11

A Data are presented as the mean cell number ± standard deviation based on a total of 10 000 events collected. N = 6 animals/sex/dose.

^*P < .05 from the 0 mg/kg group of the same sex.