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. 2018 May 2;37(32):4385–4397. doi: 10.1038/s41388-018-0278-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Antagonizing CD105 confers radio-sensitivity in vivo. a Tumor volumes were longitudinally measured. When tumor average volume reached 80 mm³ mice were treated with IgG or TRC105 (T) in the context of radiation (2 Gy for 5 days). Tumors were harvested 15 days after the first dose of radiation (n = 6). b Tumor volume fold change was normalized to the first dose of radiation (^†p = 1 × 10⁻⁹). Each treatment was compared for doubling of tumor volume as a function of time as depicted in the cumulative incidence plot. d Histochemical localization of SIRT1, phosphorylated histone H3, and survivin was performed on paraffin-embedded tumor tissues. Phosphorylated histone H3 and survivin expression was quantitated as a measure of total cells per field per tumor (**p < 0.01, ***p < 0.001)