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. 2018 Aug 9;8:11904. doi: 10.1038/s41598-018-30383-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Conservation of the N¹-methyladenosine in helix 25.1 of 25/28S rRNA. (A) rRNA sequence alignment of helix 25.1 from S. cerevisiae, C. albicans, S. pombe and H. sapiens. The m¹A modified residue is highly conserved within helix 25.1 (B) Overlaid RP-HPLC chromatograms of nucleosides derived from fragments isolated using mung bean nuclease assay, containing m¹A₆₄₃ (Ca-Oligo643) isolated from wild-type C. albicans strain RM1000, m¹A₆₇₀ (Sp-Oligo643) isolated from wild-type S. pombe strain CBS356 and m¹A₁₃₂₂ (Hs-Oligo1322) isolated from HCT116 cells. Cm (2′-O-ribose methylated cytidine) and Am (2′-O-ribose methylated adenosine) peaks are also labelled.