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. 2018 Aug 9;8:11905. doi: 10.1038/s41598-018-30309-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Knockdown of LH2 or LH3 inhibits migration and invasion. (A) qPCR and western blotting for 344SQ cells transfected with control non-targeting (NT) or LH2 siRNA. (B) qPCR and western blotting for 344SQ cells transfected with control non-targeting (NT) or LH3 siRNA. (C) Microscopic images for the 344SQ transfectants that invaded through matrigel-coated transwells. (D) The number of invaded cells in (C) were counted and normalized to that of NT siRNA transfectants, which was set as 1.0. (E) MTT assay for 344SQ transfectants. (F) qPCR and western blotting for HCC827 cells transfected with NT or LH2 siRNAs. (G) MTT assay for HCC827 transfectants. (H) Microscopic images for HCC827 transfectants that migrated through non-coated transwells. (I) The number of migrated cells were counted and expressed as mean + stdv. (J) Microscopic images for HCC827 transfectants that invaded through matrigel-coated transwells. (K) The number of invaded cells were counted and expressed as mean + stdv. Note: in all figures, *indicates t-test p < 0.05.