Table 1.
Summary of microbiological profiles of microbial keratitis in Sunderland Eye Infirmary between 2008–2012 and 2013–2017
| Organisms | 2008–2012 N = 209; N (%) |
2013–2017 N = 269; N (%) |
P-value |
|---|---|---|---|
| Gram-positive | 125 (59.8) | 183 (68.0) | 0.063 |
| Streptococcus | 32 (25.6) | 26 (14.2) | 0.012 |
| S. aureus | 33 (26.4) | 32 (17.5) | 0.060 |
| CoNS | 40 (32.0) | 84 (45.9) | 0.015 |
| Bacillus | 11 (8.8) | 21 (11.5) | 0.450 |
| Othersa | 9 (7.2) | 10 (5.5) | 0.534 |
| Gram-negative | 65 (31.1) | 62 (23.0) | 0.048 |
| Pseudomonas | 31 (47.7) | 19 (30.6) | 0.049 |
| Moraxella | 19 (29.2) | 26 (41.9) | 0.135 |
| Othersb | 15 (23.1) | 17 (27.4) | 0.573 |
| Fungi | 12 (5.7) | 8 (3.0) | 0.134 |
| Yeast | 5 (41.7) | 5 (62.5) | 0.361 |
| Filamentous | 7 (58.3) | 3 (37.5) | 0.361 |
| Acanthamoeba | 7 (3.4) | 16 (6.0) | 0.188 |
Chi-square test was used to detect any significant changing trend of the microbiological profiles between the two time periods. Significant P-values ( 0.05) are underlined. The calculation of the proportions of organisms was performed at two levels; the first level comprised Gram-positive and Gram-negative organisms, fungi and acanthamoeba; and the second level comprised the subtypes of the organisms within the four groups
CoNS coagulase-negative staphylococcus
aOther Gram-positive organisms included Aerococcus, Enterococcus, Kocuria, Micrococcus, Mycobacterium and Rothia
bOther Gram-negative organisms included Acinetobacter, Aeromonas, Burkholderia, Haemophilus, Klebsiella, Neisseria, Ochrobactrum, Raoultella, Serratia, Sphingomonas and Stenotrophomonas