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. 2018 Aug 9;8:11935. doi: 10.1038/s41598-018-29817-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Altered cytoskeletal organization drive increased stiffness in PGCCs. (A) Ensemble averaged MSDs derived from particle motion embedded within cell cytoplasm of non-PGCCs and (B) PGCCs show decreased particle motion and increased stiffness in PGCCs (over 100 traces). (C) Coefficient of variation analysis for ensemble MSDs of non-PGCC and PGCCs reveal increased heterogeneity in PGCCs. (D) Fluorescent images of non-PGCC and PGCCs (white arrow) stained with Phalloidin (F-actin, red), Anti-α-tubulin (Microtubule, green), and DAPI (Nucleus, blue). (E) Actin stress fiber quantification show increased stress fiber length and (F) width in PGCCs compared to non-PGCCs. Results are reported as the mean ± SEM. Significance is indicated as *p < 0.05, **p < 0.01, ***p < 0.001.