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. 2018 Aug 3;9:336. doi: 10.3389/fpsyt.2018.00336

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Copyright © 2018 Doucette, Dwiel, Boyce, Simon, Khokhar and Green.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Deep brain stimulation targeted to either the NAc core or shell produces significant reductions in binge size using group-based analysis but with clear individual responders and non-responders. (A) Group-based analysis (RMANOVA) with post-hoc evaluation revealed a significant difference between baseline (B) and stimulation (S) sessions but not between baseline and post-stimulation (PS) sessions with either core or shell targeted stimulation (^*p 0.05, boxplots-95% CI). (B) Individual rat responses to core stimulation with responders (black, 4/9) and non-responders (gray, 5/9). Horizontal lines illustrate ± 2 standard deviations (± 26%). (C) Individual rat responses to shell stimulation with responders (black, 5/9) and non-responders (gray, 4/9).