Figure 4.

Variation in reward-related behavior and electrode location does not relate to stimulation outcomes. Normalized behavioral data grouped by core (A) and shell (B) DBS response type–responders (R; black) and non-responders (NR; gray). No significant differences were observed between R and NR groups for the following outcomes: (1) total distance traveled during locomotor response to novelty (LRN); (2) change in the percent of time spent in the initially non-preferred chamber during conditioned place preference (CPP); and (3) percentage increase in food intake after 24 h of food deprivation (DEP). (C) All rats included in the analysis had electrode locations within the bilateral NAc core and shell with electrodes localized within the black shapes collapsed onto two representative coronal sections. The largest variation in electrode positioning occurred along the anterior-posterior (A-P) dimension (1.4 to 2.4 mm anterior to bregma). No discernable relationship between electrode placement along the A-P axis in NAc core (D) or shell (E) corresponded to stimulation outcomes – responder (black) or non-responder (gray).