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. 2018 Aug 3;9:1613. doi: 10.3389/fimmu.2018.01613

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Copyright © 2018 Manjarrez-Orduño, Menard, Kansal, Fischer, Kakrecha, Jiang, Cunningham, Greenawalt, Patel, Yang, Golhar, Carman, Lezhnin, Dai, Kayne, Suchard, Bernstein and Nadler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Peripheral T cell subpopulations show evidence of an ongoing immune response in cancer patients. (A) Gating strategy to define T cell subpopulations in PBMC. (B) CD4⁺ and CD8⁺ T cell subpopulations in PBMC from melanoma and NSCLC patients. (C) Percentage of PD1+ cells per T cell subpopulation (controls n = 27, melanoma n = 43, NSCLC n = 40; Bonferroni-corrected p-values: *<0.001). Line marks the median.

Peripheral T cell subpopulations show evidence of an ongoing immune response in cancer patients. (A) Gating strategy to define T cell subpopulations in PBMC. (B) CD4⁺ and CD8⁺ T cell subpopulations in PBMC from melanoma and NSCLC patients. (C) Percentage of PD1+ cells per T cell subpopulation (controls n = 27, melanoma n = 43, NSCLC n = 40; Bonferroni-corrected p-values: *<0.001). Line marks the median.