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. 2018 Aug 3;9:1613. doi: 10.3389/fimmu.2018.01613

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Copyright © 2018 Manjarrez-Orduño, Menard, Kansal, Fischer, Kakrecha, Jiang, Cunningham, Greenawalt, Patel, Yang, Golhar, Carman, Lezhnin, Dai, Kayne, Suchard, Bernstein and Nadler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Local immune responses in melanoma and NSCLC correlate with circulating central memory (CM)/effector (Eff) T cell ratios. (A) SPADE-generated maturation profiles of CD8⁺ T cells for two melanoma samples showing the divergent patterns of T cell subpopulations. Both have a reduction in naïve CD8⁺ T cells but show an expansion in either CM (solid arrow) or the Eff (open arrow) compartments. eEM, early Effector Memory; EM, Effector Memory. (B) Correlation between circulating CM and Eff CD4⁺ and CD8⁺ T cells and tumor inflammation state (*p < 0.05). (C) Correlation between CM/Eff T cell ratios by inflammation state in melanoma and NSCLC. Fisher’s exact test p-value for a 0.05 significance level. Dividing line generated based on the 90th percentile of controls.