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. 2018 Aug 3;9:1782. doi: 10.3389/fimmu.2018.01782

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Copyright © 2018 Elliott, Singh, Nagarkatti and Nagarkatti.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Altered expression profile of myeloid-derived suppressor cells (MDSCs) following cannabidiol (CBD) treatment. Absolute cell counts for MDSC: cells were isolated from intraperitoneal lavage (A), spinal cord and brain (B) on indicated day. Cells were stained with CD11b and Gr-1 (MDSC) then enumerated using total cell count and frequency from flow cytometry. Data represented as mean ± SEM (n = 3–5 per sample). Suppressive function of CBD-induced MDSCs was tested using ex vivo restimulation of experimental autoimmune encephalomyelitis (EAE)-VEH splenocytes in the presence of MOG35–55 (30 μg/mL) for 3 days. Cells were pulsed with thymidine and analyzed using BetaScint Counter and were assessed for proliferation (C) and total viable cell number (D). Data represented as mean ± SEM. ANOVA, ***p < 0.0001, **p < 0.001, and *p < 0.05 with Tukey’s post hoc test.