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. 2018 Aug 3;9:1799. doi: 10.3389/fimmu.2018.01799

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Copyright © 2018 Wang, Zhang, Fan, Chen, Luan, Nan, Wang, Chen, Zhang, Wu and Ju.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Rituximab-monomethyl auristatin E (MMAE) induced apoptosis in non-Hodgkin lymphoma cells. Apoptosis induced by Rituximab-MMAE was detected by western blot and flow cytometry (FCM). Ramos and Daudi cells were incubated in different concentration of Rituximab-MMAE. (A,B) Apoptosis was detected by FCM. The percentage of Annexin V+ PI− and Annexin V+ PI+ cells (apoptosis cells) was shown in right bar chart. (C,D) The protein level of poly ADP-ribose polymerase (PARP), cleaved PARP, cleaved caspase 9, cleaved caspase 3, Bax, and Bcl-2 was detected by western blot; β-actin was used as a loading control. Densitometric values were quantified by Image J software.