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. 2018 Aug 3;11:270. doi: 10.3389/fnmol.2018.00270

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Copyright © 2018 Wen, Binder, Ethell and Razak.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Structural composition of PNN. Lecticans are attached to a hyaluronan backbone via link proteins such as cartilage link protein and hyaluronan link proteins (not pictured). Hyaluronan synthase contributes to hyaluronan synthesis and anchors hyaluronan to the cell membrane. Tenascin promotes crosslinking of lecticans and helps maintain PNN structural integrity. PNN around PV cells may provide protection from redox dysregulation and oxidative stressors such as superoxide free radicals (O₂^-) and metal ions (Fe). In addition, PNNs may facilitate PV maturation through internalization of Otx2 homeoproteins and regulate PV cell excitability through accumulation of the immediate early gene and synaptic scaling molecule Narp (see Fragile X Syndrome). Narp, neuronal activity-regulated pentraxin; Otx2, orthodenticle homeoprotein 2.