Table 1.
Clinical characteristics of the studied Chinese Han population.
| Characteristics | Stage 1-discovery |
P | Stage 2-validation |
P | Stage 3-replication |
P | Combined |
P | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAD | Control | CAD | Control | CAD | Control | CAD | Control | |||||
| Subject numbers | 1,345 | 1,156 | – | 1,347 | 1,156 | – | 936 | 1,464 | – | 3,628 | 3,776 | – |
| Age (years) | 67.8 ± 11.4 | 59.2 ± 9.94 | 0.00 | 63.1 ± 11.8 | 61.0 ± 10.6 | 0.00 | 60.7 ± 10.4 | 58.1 ± 11.6 | 0.00 | 64.2 ± 11.7 | 59.3 ± 10.9 | 0.00 |
| Gender (male, %) | 58.8 | 61.9 | 0.11 | 73.6 | 53.9 | 0.00 | 54.2 | 66.7 | 0.00 | 63.1 | 61.3 | 0.12 |
| Smoking (%) | 23.0 | 22.1 | 0.59 | 31.3 | 14.1 | 0.00 | 36.1 | 25.4 | 0.00 | 29.4 | 20.9 | 0.00 |
| BMI (kg/m2) | 24.4 ± 0.35 | 24.0 ± 1.92 | 0.00 | 24.4 ± 1.28 | 23.9 ± 1.25 | 0.00 | 25.0 ± 2.17 | 24.3 ± 0.68 | 0.00 | 24.6 ± 1.39 | 24.1 ± 1.35 | 0.00 |
| Hypertension (%) | 75.2 | 54.4 | 0.00 | 68.0 | 22.5 | 0.00 | 61.4 | 42.1 | 0.00 | 69.0 | 39.9 | 0.00 |
| DM (%) | 29.4 | 24.0 | 0.00 | 22.6 | 8.13 | 0.00 | 15.0 | 7.58 | 0.00 | 23.2 | 12.8 | 0.00 |
| Tch (mmol/L) | 4.39 ± 1.01 | 4.28 ± 0.74 | 0.00 | 4.51 ± 1.05 | 4.23 ± 0.76 | 0.00 | 4.60 ± 1.19 | 4.39 ± 0.24 | 0.00 | 4.49 ± 1.07 | 4.31 ± 0.61 | 0.00 |
| TG (mmol/L) | 1.56 ± 1.07 | 1.50 ± 0.65 | 0.14 | 1.78 ± 1.04 | 1.48 ± 0.67 | 0.00 | 1.82 ± 1.30 | 1.51 ± 0.50 | 0.00 | 1.71 ± 1.13 | 1.50 ± 0.60 | 0.00 |
| HDL-c (mmol/L) | 1.11 ± 0.27 | 1.18 ± 0.22 | 0.00 | 1.12 ± 0.26 | 1.18 ± 0.20 | 0.00 | 1.19 ± 0.36 | 1.26 ± 0.07 | 0.00 | 1.13 ± 0.29 | 1.21 ± 0.18 | 0.00 |
| LDL-c (mmol/L) | 2.62 ± 0.83 | 2.46 ± 0.64 | 0.00 | 2.64 ± 0.80 | 2.42 ± 0.66 | 0.00 | 2.59 ± 0.67 | 2.41 ± 0.25 | 0.00 | 2.62 ± 0.78 | 2.43 ± 0.53 | 0.00 |
The data are presented as mean ± SD or percentages.
CAD, coronary artery disease; BMI, body mass index; DM, diabetes mellitus; Tch, total cholesterol; TG, triglyceride; HDL-c, high-density lipoprotein cholesterol; LDL-c, low-density lipoprotein cholesterol.