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. 2018 Aug 3;9:1692. doi: 10.3389/fimmu.2018.01692

Figure 3.

Figure 3

Serum chemokines and gut eosinophil levels in IKKβΔIEC mice following oral sensitization and oral allergen challenge. (A) Serum chemokines. Serum samples were collected 2 h after allergen challenge on day 30 and the concentrations of chemokines were evaluated by multiplex assay. Data are expressed as mean ± SD. *p < 0.05; **p < 0.01 and are from at least five experiments and five mice/group. (B–D) Analysis of small intestinal tissues collected on day 30 and 2 h after allergen challenge of wild-type and IKKβΔIEC mice. (B) Eotaxin-1 (Ccl11), eotaxin-3 (Ccl24), il-25, and Tslp mRNA levels. (C) Eosinophils in small intestine. Thin sections of small intestinal tissues were stained with an anti-Siglec-F antibody and counterstained with DAPI to visualize nuclei. (D) Il-5 and eosinophil peroxide (Epx) mRNA levels. The mRNA data are expressed as mean ± SD. *p < 0.05; **p < 0.01, and are from at least five experiments and five mice/group.