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. 2018 Aug 3;5:207. doi: 10.3389/fmed.2018.00207

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Copyright © 2018 Tolusso, Gigante, Alivernini, Petricca, Fedele, Di Mario, Aquilanti, Magurano, Ferraccioli and Gremese.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Chemerin, PEDF, IL6 and their receptors expression in White Adipose Tissue (WAT) of obese RA patients with low-moderate disease activity and in obese OA. (A) IL6, RARRES2, and SERPINF1 expression and (B) CMKLR1 and IL6-R were determined in abdominal WAT from obese RA (n = 27) and obese OA (n = 10). Levels of target genes mRNA expression were determined, after normalization with GAPDH values, using the 2−^ΔΔC_T method. Horizontal lines indicate mean values with SD. RA, Rheumatoid Arthritis; OA, Osteoarthritis; LDA, Low disease activity (1.6 < DAS < 2.4); MDA, Moderate disease activity (2.4 < DAS < 3.7); IL6, Interleukin 6; RARRES2, retinoic acid receptor responder protein 2; CMKLR1, Chemokine like receptor 1; IL6-R, interleukin-6 receptor.