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. 2018 Aug 3;8:259. doi: 10.3389/fcimb.2018.00259

Figure 1.

Figure 1

Impact of TNFR1 signaling in the early events after the onset of S. aureus sepsis of peritoneal origin. Groups of C57BL/6 wild type and tnfr1−/− mice were inoculated with S. aureus FPR3757 by intraperitoneal route. (A) The presence of bacteria in blood were monitored 4 h and 1 day post-inoculation. Bars represent the percentage of mice with bacteriemia. (B) Weight loss were quantified at day 1 post-inoculation. (C) Plasma levels of IL-6 4 h post-inoculation were quantified by ELISA. The levels of IL-6 before inoculation were below the detection limit (15 pg/ml). (B,C) Boxes and whiskers depict maximum and minimum values obtained from individual mice and the horizontal line represents the median for each group. *p < 0.05, ***p < 0.001, compared with values obtained from the same group before inoculation, Mann-Whitney U-test for nonparametric data. hpi: hours post-inoculation, dpi: days post-inoculation.