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. 2018 Aug 3;8:259. doi: 10.3389/fcimb.2018.00259

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Copyright © 2018 Ledo, Gonzalez, Poncini, Mollerach and Gómez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Role of TNFR1 in the accumulation of MDSC in the spleen. Groups of C57BL/6 wild type and tnfr1^−/− mice were inoculated with S. aureus FPR3757 by intraperitoneal route. (A,B) MDSC were purified from the spleen at day 8 post-inoculation. The relative expression levels of S100A8 (A) and S100A9 (B) mRNA in this population were determined by RT real-time PCR and normalized to GAPDH. (a.u.): arbitrary units. Mann-Whitney U-test for nonparametric data. (C) Correlation analysis between plasmatic levels of IL-6 in C57BL/6 wild type (squares) and tnfr1^−/− (circles) mice 4 h post-inoculation and the percentage of MDSC present in the spleen at day 8 post-inoculation. Data were analyzed using the Spearman test.