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. 2018 Aug 3;8:259. doi: 10.3389/fcimb.2018.00259

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Copyright © 2018 Ledo, Gonzalez, Poncini, Mollerach and Gómez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of immunosuppressive mediators by MDSC. Groups of C57BL/6 wild type (A–D) and tnfr1^−/− (A,B) mice were inoculated with S. aureus FPR3757 (SA, gray circles and bars) by intraperitoneal route. (A,B) The MDSC present in the spleen were purified at day 8 post-inoculation and the relative expression of Arg-1 (A) and iNOS (B) in this population was determined by RT real-time PCR and normalized to GAPDH. (a.u.): arbitrary units. Mann-Whitney U-test for nonparametric data. (C,D) The presence of Arginase and iNOS was determined by intracellular staining and flow cytometry in MDSC from wild type mice inoculated with S. aureus or PBS (control). (C) ΔMFI: Mean Fluorescence Intensity (MFI) infected - MFI control. (D) Representative histograms are shown.