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. 2018 Aug 3;9:857. doi: 10.3389/fphar.2018.00857

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Copyright © 2018 Wu, Liu, Wei, Li, Zang, Qian, Bai, Li, Xie, Zhu, Wang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Siah1 may inhibit WISP1 expression in PDAC cells. After lentivirus-mediated Siah1 silencing vector or control was stably transduced into Capan-2 cells (Tp53 wild-type), lentivirus-mediated Siah1 overexpression vector or control was stably transduced into Panc-1 cells (Tp53 mutation), and then immunofluorescence staining was performed to measure the levels and locations of Siah1 and WISP1 in Capan-2 (A,B) and Panc-1 cells (C,D) (white bar scale = 10 μm). Immunohistochemistry staining of Siah1 and WISP1 was performed, and Pearson’s correlation test was also used to analyze the correlation between Siah1 and WISP1 according to immunohistochemistry staining (E,F) (black bar scale = 25 μm).