Fig. 2.

Gene expression pattern and signaling pathway analysis according to the Lymph2Cx COO assignment. (a) The expression of 163 genes in our 805-gene NanoString panel by 196 of the 211 samples in this study. The expression of these 163 genes was significantly different between the ABC, GCB and Unclassified subgroups. The genes were further clustered into 4 groups (shown by the color bars at the left of the heatmap). The Lymph2Cx COO assignments are shown by the color bar at the top of the heatmap. (b) Median gene expression values (left; each data point represents one sample) and pathway analysis results (right) for the 4 gene groups identified in panel A. Labels at the left of the horizontal bars show the top 10 most differentially up-regulated signaling pathways by the COO subtype with higher expression of that gene group.