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. 2018 Jun 20;33:94–104. doi: 10.1016/j.ebiom.2018.06.010

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 4 — MYC protein expression and immune characteristics. (a) Representative images of MYC IHC staining. (b) MYC gene expression by samples of high and low MYC IHC staining. “*” indicates p < 0.05. (c) The expression of 90 genes in our 805-gene NanoString panel by 144 of the 211 samples in this study. The expression of these 90 genes was significantly different between MYC-Low and MYC-High subgroups. The MYC protein expression status and Lymph2Cx COO assignments are shown by the color bars at the top of the heatmap. (d) Expression of immune gene signatures. “*” indicates p < 0.05. (e) Expression of selected potential immunotherapy targets. Note that CD274 codes for PD-L1 and TNFRSF4 codes for OX40. “*” indicates p < 0.05.