Fig. 5.

Cy7-BC71 home to 4 T1 breast tumor in subcutaneous xenograft mouse tumor model. (a) Comparison of whole-body near-infrared fluorescence of subcutaneous 4 T1 tumor bearing mice injected with 1 nmol of Cy7-BC71, Cy7-GR35 or Cy7 dye alone at 2 h, 12 h, 24 h, 48 h, 72 h p.i. The position of tumor is indicated with white arrows and all images are normalized to the same scale. (b) Quantification of fluorescence intensity of the tumor as a function of time after the injection of the Cy7-BC71, Cy7-GR35 or Cy7 dye (c) Ex-vivo fluorescence intensity of various organs at 72 h p.i. The data is represented as Mean ± S.D. (n = 5 for each group), **p = 0.0073.