Fig. 4.

Protein STRING network of ALS regulation. The gene loci for the top 150 chromosome conformations that could best discriminate between ALS samples and healthy controls in the second array screen were uploaded as proteins to the STRING database and a resulting interaction network was generated. The two main networks are shown. Network nodes represent proteins and edges represent protein-protein associations. All nodes shown are query proteins and the first shell of interactors. Nodes are colored according to their association with the top gene ontology (GO) terms for Biological Process and Cellular Component. Edges are colored according to their interactions, either known, predicted or other.