Table 4.
List of immune-related genomic loci tested in the initial ALS array.
| Gene name | Array probe count | Gene name | Array probe count | Gene name | Array probe count |
|---|---|---|---|---|---|
| VCAM1 | 10 | IGHV3-23 | 13 | CD40 | 7 |
| RAP1A | 332 | IGHV1-46 | 2 | CXADR | 8 |
| NRAS | 12 | TRAV19 | 5 | IFNAR2 | 24 |
| CD160 | 24 | TRAC | 12 | IFNAR1 | 4 |
| FCGR1A | 23 | ADCY4 | 10 | IFNGR2 | 90 |
| RFX5 | 24 | LGALS3 | 7 | DONSON | 5 |
| THEM4 | 88 | RASGRP1 | 9 | ICOSLG | 12 |
| IL6R | 138 | B2M | 30 | ICOSLG;AIRE | 3 |
| FCER1A | 2 | CIITA | 4 | ITGB2 | 14 |
| FCER1G | 24 | PRKCB | 415 | VPREB1 | 1 |
| FCGR2A | 19 | PDPK1 | 51 | IGLV7-43 | 8 |
| FCGR3A;FCGR2A | 4 | IL21R | 56 | IGLC3;IGLC7;IGLC2;IGLC1;IGLC6 | 2 |
| FCGR3A | 42 | CD19 | 10 | BCR | 100 |
| FCGR2B;FCGR3A | 125 | LAT | 22 | IGLL1 | 10 |
| CD247 | 254 | ITGAL | 23 | SEC14L3 | 12 |
| SELL | 52 | ITGAM | 54 | CSF2RB | 15 |
| DNM3 | 1121 | ADCY9 | 132 | IL2RB | 4 |
| PTPRC | 154 | CDH1 | 154 | MKL1 | 183 |
| CHI3L1 | 38 | PLCG2 | 221 | TNFRSF13C | 4 |
| C4BPB | 9 | GINS2 | 27 | IRAK2 | 38 |
| C4BPB;C4BPA | 10 | TNFRSF13B | 7 | CBLB | 51 |
| C4BPA | 35 | CPD | 61 | CD96 | 159 |
| CD55 | 33 | AP2B1 | 44 | CD200 | 26 |
| CR2 | 15 | ERBB2 | 6 | CD200R1 | 9 |
| CR1;CR2 | 6 | PLD2 | 10 | CD80 | 21 |
| CR1 | 205 | C1QBP | 36 | CD86 | 11 |
| CD46 | 11 | MRC2 | 51 | ADCY5 | 153 |
| CD34 | 70 | CD300LB | 5 | ITGB5 | 63 |
| DDOST | 11 | CD300E | 10 | NCK1 | 95 |
| TLR5 | 53 | GRB2 | 270 | TRPC1 | 21 |
| LYPLA2 | 30 | GUCY2D | 13 | PLD1 | 201 |
| AKT3 | 437 | SIGLEC15 | 2 | AP2M1 | 13 |
| CLIC4 | 479 | MALT1 | 32 | IL1RAP | 29 |
| IFI6 | 116 | CD226 | 15 | IL5RA | 11 |
| PTAFR | 49 | ICAM1 | 9 | MYD88 | 8 |
| ATPIF1;PTAFR | 14 | ICAM1;ICAM4 | 1 | CCR2 | 2 |
| ATPIF1 | 24 | DNM2 | 235 | DAPP1 | 26 |
| LCK | 158 | PRKCSH | 31 | NFKB1 | 27 |
| BCL10 | 18 | ACP5 | 23 | TLR2 | 5 |
| PIK3CD | 191 | JAK3 | 21 | CD38 | 24 |
| CHUK | 15 | RFXANK | 33 | TLR10 | 2 |
| NFKB2 | 5 | HCST | 3 | TLR1;TLR10 | 3 |
| PPAPDC1A | 19 | TYROBP;HCST | 5 | TLR1 | 4 |
| FGFR2 | 95 | TYROBP | 12 | TLR1;TLR6 | 3 |
| MRC1 | 23 | MATK | 27 | KLB | 27 |
| ITGB1 | 29 | AKT2 | 34 | PDGFRA | 69 |
| IL2RA | 7 | AKT2;PLD3 | 6 | KIT | 32 |
| PRKCQ | 164 | PLD3 | 23 | TICAM2 | 12 |
| FAS | 16 | CD79A | 6 | CD14 | 55 |
| BLNK | 35 | MADCAM1 | 3 | PDGFRB | 18 |
| PIK3AP1 | 210 | PVR | 8 | CD74 | 6 |
| AP2A2 | 20 | PVRL2 | 43 | FGFR4 | 28 |
| NCAM1 | 43 | PTGIR | 42 | PRLR | 41 |
| AMICA1 | 16 | AP2S1 | 10 | IL7R | 14 |
| CD3E | 13 | AP2A1 | 22 | GHR | 114 |
| CD3G | 3 | SIGLEC16 | 10 | CCNO | 7 |
| CD3D | 2 | SIGLEC14 | 3 | IL6ST | 24 |
| CD3G;CD3D | 1 | LILRB2 | 2 | CD180 | 1 |
| CXCR5 | 13 | LILRB1 | 10 | PIK3R1 | 14 |
| CBL | 41 | LILRB4 | 13 | ADCY2 | 364 |
| CRTAM | 11 | KIR2DL4;KIR3DL1;KIR2DL3 | 13 | FYN | 332 |
| TIRAP | 2 | KIR2DL4;KIR3DL1 | 11 | IFNGR1 | 15 |
| CD81 | 3 | KIR3DL1 | 4 | TAB2 | 150 |
| IFITM1;IFITM2 | 4 | KIR2DL1;KIR2DL4;KIR3DL1;KIR2DL3 | 5 | ULBP1 | 14 |
| IFITM3 | 6 | KIR2DS4;KIR3DL1 | 1 | ULBP3 | 34 |
| CD59 | 7 | KIR2DS4;KIR3DL1;KIR3DL2 | 2 | CCR6 | 11 |
| CD44 | 24 | C3 | 28 | MICB | 28 |
| ART1 | 1 | VAV1;C3 | 3 | CFB | 2 |
| RAG1;TRAF6 | 8 | VAV1 | 49 | C4A | 3 |
| RAG1 | 46 | IL1R2 | 5 | C4B | 1 |
| RAG2;RAG1 | 10 | IL1R1 | 56 | AGER | 7 |
| RAG2 | 8 | IL1RN | 9 | TAP2;TAP1 | 3 |
| SIGIRR | 1 | RAPGEF4 | 195 | TAP1 | 4 |
| HRAS | 14 | ITGA4 | 1 | TREM2 | 5 |
| MS4A2 | 12 | ITGAV | 1 | TREM1 | 9 |
| SCYL1 | 9 | CD28 | 2 | NCR2 | 5 |
| PANX1 | 29 | ICOS | 10 | LY86 | 54 |
| KLRD1 | 53 | IRS1 | 6 | MAP3K7 | 2 |
| KLRK1 | 3 | PDCD1 | 2 | EPHB4 | 30 |
| UNG | 18 | ADCY3 | 30 | CLEC5A | 7 |
| P2RX7 | 53 | RASGRP3 | 41 | CARD11 | 50 |
| ORAI1 | 22 | SOS1 | 177 | ADCY1 | 30 |
| KRAS | 5 | ACTR2 | 46 | EGFR | 209 |
| RAPGEF3 | 15 | CD8A | 9 | LAT2 | 9 |
| ADCY6 | 7 | CD8A;CD8B | 14 | CD36 | 127 |
| ITGB7 | 6 | CD8B | 22 | ADCY8 | 121 |
| GLYCAM1 | 6 | IGKV1-5 | 10 | PPAPDC1B | 26 |
| ERBB3 | 2 | IGKV3-7 | 7 | FGFR1 | 7 |
| CD4 | 57 | IGKV3-11 | 3 | IKBKB | 18 |
| RAP1B | 33 | IGKV3-15 | 10 | LYN | 179 |
| FRS2 | 63 | IGKV3-20 | 3 | PAG1 | 73 |
| AICDA | 3 | IGKV2-30 | 8 | TLR4 | 10 |
| KLRG1 | 15 | IGKV1D-16 | 8 | ANGPTL2 | 4 |
| IRS2 | 1 | MAL | 3 | DNM1 | 11 |
| ARHGEF7 | 94 | ADAM17 | 17 | SH3GL2 | 101 |
| KL | 23 | ZAP70 | 10 | CLTA | 110 |
| RFXAP | 26 | SIRPB1 | 4 | CD274 | 1 |
| DLEU2 | 20 | GINS1 | 39 | PDCD1LG2 | 1 |
| AKT1 | 18 | TRIB3 | 21 | SYK | 25 |
| CD40LG | 3 | PLCG1 | 12 | BTK | 8 |
| IL3RA;CSF2RA | 3 | ADA | 9 | CSF2RA | 25 |
| IL3RA | 15 | IKBKG | 2 | TAB3 | 35 |
| IRAK1 | 5 | SH3KBP1 | 291 | Total | 13,880 |